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Xiaoxi Zhuang

TitleProfessor
InstitutionUniversity of Chicago
DepartmentNeurobiology
AddressChicago IL 60637
Email
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    Collapse Overview 
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    We investigate the molecular machinery underlying synaptic plasticity and information processing in the brain. We are especially interested in synaptic mechanisms supporting reinforcement learning and motor control. Our main approaches include mouse genetics, fly genetics, optogenetics, animal learning paradigms, electrophysiology, molecular biology and RNA-seq.
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    Collapse Research 
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    R21NS132597     (ZHUANG, XIAOXI)Jun 1, 2023 - May 31, 2025
    NIH
    Generating mouse models with cell type-specific and reversible GABA deficiency
    Role: Principal Investigator
    R21DA057073     (ZHUANG, XIAOXI)Aug 15, 2022 - Jul 31, 2024
    NIH
    Postsynaptic mechanisms underlying negative prediction error
    Role: Principal Investigator
    R01NS111122     (ZHUANG, XIAOXI)Dec 1, 2019 - Nov 30, 2024
    NIH
    Drosophila and mouse models of PNPO deficiency
    Role: Principal Investigator
    R01MH122142     (DICKINSON, BRYAN)Sep 25, 2019 - Jul 31, 2024
    NIH
    Base-resolution mapping and site-specific epitranscriptomic studies in the brain
    Role: Co-Principal Investigator
    R21NS103159     (DELGADO, JARY YAMIR)Mar 1, 2018 - Feb 29, 2020
    NIH
    Dynamics of m6A methylated Arc mRNA
    Role: Co-Principal Investigator
    R01DA043361     (ZHUANG, XIAOXI)Sep 1, 2017 - May 31, 2022
    NIH
    RNA methylation in synaptic plasticity and drug-seeking
    Role: Principal Investigator
    T32DA043469     (HEDEKER, DONALD)Jul 1, 2017 - Jun 30, 2027
    NIH
    Integrative Training in the Neurobiology of Addictive Behaviors
    Role: Co-Principal Investigator
    R01NS095374     (ZHUANG, XIAOXI)May 15, 2016 - Apr 30, 2021
    NIH
    Preventing Experience Dependent Aberrant Plasticity Under Dopamine Deficiency
    Role: Principal Investigator
    R21DA039629     (ZHUANG, XIAOXI)Jul 1, 2015 - Jun 30, 2017
    NIH
    Genetic dissection of neural pathways for appetitive associative learning
    Role: Principal Investigator
    R21NS083383     (ZHUANG, XIAOXI)Apr 1, 2013 - Mar 31, 2015
    NIH
    Nicotine mitigates dopamine blockade-induced aberrant plasticity and learning
    Role: Principal Investigator
    R01GM100768     (ZHUANG, XIAOXI)Apr 1, 2012 - Mar 31, 2017
    NIH
    Genomic analysis of feeding behavior and fitness in Drosophila
    Role: Principal Investigator
    R56DK088515     (ZHUANG, XIAOXI)Aug 15, 2010 - Jul 31, 2011
    NIH
    Reward mechanisms in feeding and obesity
    Role: Principal Investigator
    R21NS070269     (ZHUANG, XIAOXI)Feb 1, 2010 - Jan 31, 2012
    NIH
    Animal models of dopamine-independent motor control
    Role: Principal Investigator
    R21NS062425     (ZHUANG, XIAOXI)Sep 1, 2009 - Aug 31, 2011
    NIH
    Targeting adenylyl cyclase to prevent L-DOPA-induced dyskinesia
    Role: Principal Investigator
    R03NS058415     (ZHUANG, XIAOXI)Jun 1, 2008 - Apr 30, 2010
    NIH
    Gene Dose Effect of DJ-1 and PINK1 on Tissue Degeneration
    Role: Principal Investigator
    R03DA022269     (ZHUANG, XIAOXI)Sep 25, 2006 - Aug 31, 2008
    NIH
    Epigenetic Mechanisms in Motor Habits Stability
    Role: Principal Investigator
    R01MH066216     (ZHUANG, XIAOXI)Dec 3, 2003 - Nov 30, 2008
    NIH
    GENETIC AND BEHAVIORAL DISSECTION OF INHIBITORY CONTROL
    Role: Principal Investigator
    R21AR048808     (ZHUANG, XIAOXI)Sep 28, 2001 - Aug 31, 2004
    NIH
    MUTAGENESIS PERMITTING CONTROLLED GENE EXPRESSION
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Shi Z, Wen K, Zou Z, Fu W, Guo K, Sammudin NH, Ruan X, Sullere S, Wang S, Zhang X, Thinakaran G, He C, Zhuang X. YTHDF1 mediates translational control by m6A mRNA methylation in adaptation to environmental challenges. bioRxiv. 2024 Aug 09. PMID: 39149343; PMCID: PMC11326287.
      Citations:    
    2. Kahl M, Xu Z, Arumugam S, Edens B, Fischietti M, Zhu AC, Platanias LC, He C, Zhuang X, Ma YC. m6A RNA methylation regulates mitochondrial function. Hum Mol Genet. 2024 05 18; 33(11):969-980. PMID: 38483349; PMCID: PMC11102592.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    3. Zou Z, Wei J, Chen Y, Kang Y, Shi H, Yang F, Shi Z, Chen S, Zhou Y, Sepich-Poore C, Zhuang X, Zhou X, Jiang H, Wen Z, Jin P, Luo C, He C. FMRP phosphorylation modulates neuronal translation through YTHDF1. Mol Cell. 2023 Dec 07; 83(23):4304-4317.e8. PMID: 37949069; PMCID: PMC10872974.
      Citations: 22     Fields:    Translation:HumansCells
    4. Zhang HJ, Zammit M, Kao CM, Govind AP, Mitchell S, Holderman N, Bhuiyan M, Freifelder R, Kucharski A, Zhuang X, Mukherjee J, Chen CT, Green WN. Trapping of Nicotinic Acetylcholine Receptor Ligands Assayed by In Vitro Cellular Studies and In Vivo PET Imaging. J Neurosci. 2023 01 04; 43(1):2-13. PMID: 36028313; PMCID: PMC9838697.
      Citations: 4     Fields:    Translation:Animals
    5. Chi W, Iyengar ASR, Fu W, Liu W, Berg AE, Wu CF, Zhuang X. Drosophila carrying epilepsy-associated variants in the vitamin B6 metabolism gene PNPO display allele- and diet-dependent phenotypes. Proc Natl Acad Sci U S A. 2022 03 01; 119(9). PMID: 35217610; PMCID: PMC8892510.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    6. Chi W, Liu W, Fu W, Xia S, Heckscher ES, Zhuang X. RNA-binding protein syncrip regulates starvation-induced hyperactivity in adult Drosophila. PLoS Genet. 2021 02; 17(2):e1009396. PMID: 33617535; PMCID: PMC7932510.
      Citations: 5     Fields:    Translation:AnimalsCells
    7. Koranda JL, Dore L, Shi H, Patel MJ, Vaasjo LO, Rao MN, Chen K, Lu Z, Yi Y, Chi W, He C, Zhuang X. Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning. Neuron. 2018 07 25; 99(2):283-292.e5. PMID: 30056831; PMCID: PMC6082022.
      Citations: 79     Fields:    Translation:Animals
    8. Koranda JL, Krok AC, Xu J, Contractor A, McGehee DS, Beeler JA, Zhuang X. Chronic Nicotine Mitigates Aberrant Inhibitory Motor Learning Induced by Motor Experience under Dopamine Deficiency. J Neurosci. 2016 05 11; 36(19):5228-40. PMID: 27170121; PMCID: PMC4863059.
      Citations: 5     Fields:    Translation:AnimalsCells
    9. Beeler JA, Faust RP, Turkson S, Ye H, Zhuang X. Low Dopamine D2 Receptor Increases Vulnerability to Obesity Via Reduced Physical Activity, Not Increased Appetitive Motivation. Biol Psychiatry. 2016 06 01; 79(11):887-97. PMID: 26281715; PMCID: PMC4728060.
      Citations: 33     Fields:    Translation:Animals
    10. Chen L, Xie Z, Turkson S, Zhuang X. A53T human a-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration. J Neurosci. 2015 Jan 21; 35(3):890-905. PMID: 25609609; PMCID: PMC4300331.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    11. Augustin SM, Beeler JA, McGehee DS, Zhuang X. Cyclic AMP and afferent activity govern bidirectional synaptic plasticity in striatopallidal neurons. J Neurosci. 2014 May 07; 34(19):6692-9. PMID: 24806695; PMCID: PMC4012319.
      Citations: 19     Fields:    Translation:AnimalsCells
    12. Zhuang X, Mazzoni P, Kang UJ. The role of neuroplasticity in dopaminergic therapy for Parkinson disease. Nat Rev Neurol. 2013 May; 9(5):248-56. PMID: 23588357.
      Citations: 32     Fields:    Translation:HumansAnimals
    13. Beeler JA, Frank MJ, McDaid J, Alexander E, Turkson S, Bernardez Sarria MS, Bernandez MS, McGehee DS, Zhuang X. A role for dopamine-mediated learning in the pathophysiology and treatment of Parkinson's disease. Cell Rep. 2012 Dec 27; 2(6):1747-61. PMID: 23246005; PMCID: PMC3538862.
      Citations: 41     Fields:    Translation:AnimalsCells
    14. Beeler JA, Frazier CR, Zhuang X. Putting desire on a budget: dopamine and energy expenditure, reconciling reward and resources. Front Integr Neurosci. 2012; 6:49. PMID: 22833718; PMCID: PMC3400936.
      Citations: 57     
    15. Beeler JA, McCutcheon JE, Cao ZF, Murakami M, Alexander E, Roitman MF, Zhuang X. Taste uncoupled from nutrition fails to sustain the reinforcing properties of food. Eur J Neurosci. 2012 Aug; 36(4):2533-46. PMID: 22712685; PMCID: PMC3424366.
      Citations: 41     Translation:AnimalsPHPublic Health
    16. Beeler JA, Frazier CR, Zhuang X. Dopaminergic enhancement of local food-seeking is under global homeostatic control. Eur J Neurosci. 2012 Jan; 35(1):146-59. PMID: 22118191; PMCID: PMC3251719.
      Citations: 14     Translation:HumansAnimals
    17. Beeler JA, Daw N, Frazier CR, Zhuang X. Tonic dopamine modulates exploitation of reward learning. Front Behav Neurosci. 2010; 4:170. PMID: 21120145; PMCID: PMC2991243.
      Citations: 79     
    18. Beeler JA, Cao ZF, Kheirbek MA, Ding Y, Koranda J, Murakami M, Kang UJ, Zhuang X. Dopamine-dependent motor learning: insight into levodopa's long-duration response. Ann Neurol. 2010 May; 67(5):639-47. PMID: 20437561; PMCID: PMC3129617.
      Citations: 47     Fields:    Translation:Animals
    19. Kheirbek MA, Britt JP, Beeler JA, Ishikawa Y, McGehee DS, Zhuang X. Adenylyl cyclase type 5 contributes to corticostriatal plasticity and striatum-dependent learning. J Neurosci. 2009 Sep 30; 29(39):12115-24. PMID: 19793969; PMCID: PMC2782774.
      Citations: 52     Fields:    Translation:Animals
    20. Kheirbek MA, Beeler JA, Ishikawa Y, Zhuang X. A cAMP pathway underlying reward prediction in associative learning. J Neurosci. 2008 Oct 29; 28(44):11401-8. PMID: 18971482; PMCID: PMC2610269.
      Citations: 18     Fields:    Translation:AnimalsCells
    21. Chen L, Ding Y, Cagniard B, Van Laar AD, Mortimer A, Chi W, Hastings TG, Kang UJ, Zhuang X. Unregulated cytosolic dopamine causes neurodegeneration associated with oxidative stress in mice. J Neurosci. 2008 Jan 09; 28(2):425-33. PMID: 18184785; PMCID: PMC6670521.
      Citations: 112     Fields:    Translation:AnimalsCells
    22. Cagniard B, Beeler JA, Britt JP, McGehee DS, Marinelli M, Zhuang X. Dopamine scales performance in the absence of new learning. Neuron. 2006 Sep 07; 51(5):541-7. PMID: 16950153.
      Citations: 74     Fields:    Translation:AnimalsCells
    23. Chen L, Cagniard B, Mathews T, Jones S, Koh HC, Ding Y, Carvey PM, Ling Z, Kang UJ, Zhuang X. Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice. J Biol Chem. 2005 Jun 03; 280(22):21418-26. PMID: 15799973.
      Citations: 103     Fields:    Translation:AnimalsCells
    24. Zhuang X, Masson J, Gingrich JA, Rayport S, Hen R. Targeted gene expression in dopamine and serotonin neurons of the mouse brain. J Neurosci Methods. 2005 Apr 15; 143(1):27-32. PMID: 15763133.
      Citations: 165     Fields:    Translation:AnimalsCells
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